Weight Management
Semaglutide
Price
$179per 4 weeks
includes $30 clinician review
Physician-supervised compounded GLP-1 therapy for weight management.
- Route
- Weekly injection
- Frequency
- Once weekly
- Access
- Prescription only
- Billing
- Every 4 weeks
What it is
Semaglutide is a GLP-1 receptor agonist. The compounded preparation is prescribed by a U.S.-licensed physician and prepared and dispensed by state-licensed pharmacies, including 503A compounding pharmacies.
Published clinical trials did not study this compounded preparation, and results are not guaranteed.
Semaglutide clinical details
Semaglutide is a GLP-1 receptor agonist: a synthetic analog of the natural hormone GLP-1, modified to resist breakdown by the enzyme DPP-4 and to bind albumin in the blood, which gives it a half-life of about 7 days and is why it is dosed once a week. In published clinical trials, GLP-1 receptor agonists as a drug class were studied for their action on appetite centers in the brain, on gastric emptying, and on glucose-dependent insulin and glucagon release. Those trials studied the manufacturers' products, which are FDA-approved. The compounded preparations were not studied in these trials, and results are not guaranteed.
There are published clinical trials of GLP-1 receptor agonist medicines, including semaglutide, for weight management and cardiovascular outcomes. Those trials studied the manufacturers' products, which are FDA-approved. The compounded preparations were not studied in these trials, and results are not guaranteed. Your physician will discuss realistic expectations at consultation.
- Prescribed only when a licensed provider decides it is appropriate for you
- A weekly schedule set by your physician, started at a low dose and increased gradually
- Regular telehealth follow-up to review how you are doing and adjust your plan
- Individual results vary, and results are not guaranteed
- Nausea (most common, typically decreases over 4-8 weeks)
- Diarrhea or constipation
- Vomiting, particularly during dose escalation
- Abdominal pain or bloating
- Headache
- Fatigue
- Injection site reactions (redness, swelling)
- Decreased appetite (therapeutic effect but can be pronounced)
- Personal or family history of medullary thyroid carcinoma (MTC)
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Known hypersensitivity to semaglutide or any excipients
- History of pancreatitis
- Pregnancy or planning to become pregnant (discontinue at least 2 months before conception)
- Breastfeeding
- Severe gastroparesis or gastrointestinal disease
- End-stage renal disease (eGFR below 15 mL/min)
- Insulin or sulfonylureas - increased risk of hypoglycemia; dose adjustment may be needed
- Oral contraceptives - delayed gastric emptying may reduce absorption; consider non-oral methods
- Warfarin - monitor INR more frequently during initiation and dose changes
- Levothyroxine - absorption may be affected; take thyroid medication on an empty stomach
- Oral medications with narrow therapeutic index - monitor levels due to altered absorption timing
Follow the storage instructions provided by your pharmacy and on the medication label. Do not use if the solution appears cloudy, discolored, or contains particles.
Semaglutide frequently asked questions
Results vary from person to person, and results are not guaranteed. Your clinician discusses realistic expectations with you at consultation, based on your starting point, medical history and treatment plan. Published clinical trials were conducted on FDA-approved products, not on compounded preparations. Treatment starts at a low dose that your physician increases gradually, and your progress is reviewed at regular telehealth follow-ups.
Published clinical trials have reported that people often regain some weight after stopping GLP-1 therapy, because the biological drivers of weight regain persist after weight loss. Those trials studied the manufacturers' products, which are FDA-approved. The compounded preparations were not studied in these trials, and results are not guaranteed. Long-term planning, including any maintenance or structured tapering strategy, is decided patient-by-patient at consultation alongside sustained lifestyle modifications.
Compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality before they reach patients. A compounded preparation is not a generic version of, and is not the same as, any FDA-approved medication. It is prescribed only when a licensed provider decides it is appropriate for you. Compounded semaglutide is prepared for an individual prescription by state-licensed pharmacies, including 503A compounding pharmacies. All Pep Club pharmacy partners are state-licensed and follow USP 797 sterile-compounding standards including potency and sterility testing on every batch.
Your physician decides whether it is appropriate for you. If you are already taking diabetes medications - especially insulin or sulfonylureas - your physician will need to coordinate those medications to prevent hypoglycemia (low blood sugar). During your Pep Club consultation, disclose all current medications so your physician can create a safe, coordinated treatment plan.
Most insurance plans do not cover compounded medications. The Pep Club prices each medication per 4 weeks, billed every 4 weeks and separately from any lab panel you order, and each price includes the fee for a clinician's review of your request. Current prices are listed on our Treatment Pricing page (/treatments). Itemized receipts are provided for HSA/FSA use or out-of-network reimbursement requests.
Availability
Available where The Pep Club has a licensed physician and a licensed pharmacy partner. See the state availability page for the current list.
Also in the formulary
Ready when you are.
A two-minute eligibility check tells you if we ship to your state. A licensed physician takes it from there.
Compounded preparation
This is a compounded preparation, prepared by state-licensed pharmacies, including 503A compounding pharmacies, under U.S.-licensed physician supervision. Compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality before they reach patients. A compounded preparation is not a generic version of, and is not the same as, any FDA-approved medication. It is prescribed only when a licensed provider decides it is appropriate for you. Published clinical trials did not study this compounded preparation, and results are not guaranteed. Actual product appearance and labeling may differ from website images.