Anti-Aging
NAD+
Physician-supervised compounded NAD+ for cellular-coenzyme support.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell, used in many metabolic reactions. The Pep Club dispenses a compounded injectable preparation under U.S.-licensed physician supervision.
About this medication
NAD+ is a small molecule present in every cell, used as a coenzyme in many of the enzymatic reactions involved in energy metabolism. The molecule is consumed continually and is resynthesized by the body from dietary precursors. The Pep Club dispenses a compounded injectable preparation of NAD+ through a licensed compounding pharmacy under U.S.-licensed physician supervision. The preparation is offered as physician-supervised cellular-support therapy and is not a treatment for any specific disease. Outcomes are reviewed at each follow-up consultation.
How it works
NAD+ acts as an electron carrier in mitochondrial reactions involved in energy metabolism, and serves as a substrate or cofactor for several other intracellular enzyme families. The body synthesizes NAD+ from dietary precursors and consumes it continually. Supplementation aims to support intracellular NAD+/NADH ratios under physician supervision; outcomes are individual and cannot be guaranteed.
Clinical research context
Research on NAD+ and its precursors has been conducted in laboratory and clinical-research settings. The compounded preparation dispensed by The Pep Club is not the same as the NAD+ precursor products (NMN, NR) studied in those reports; the compounded preparation itself has not undergone equivalent finished-product efficacy testing. Your physician will discuss realistic expectations at consultation.
What patients describe
- Cellular-coenzyme support under physician supervision
- Subcutaneous administration with a schedule determined by your physician
- Patient-reported outcomes often described include changes in subjective energy or mental clarity (individual; outcomes not guaranteed)
- Physician follow-up consultations review tolerability and adjust the protocol
Side effects
- Chest tightness or pressure during IV infusion (dose-rate dependent)
- Nausea, particularly with higher doses
- Flushing and warmth at injection site
- Headache
- Mild cramping
- Fatigue during initial treatment (temporary as cells adapt)
Contraindications
- Active cancer (NAD+ may support rapidly dividing cells)
- Pregnancy or breastfeeding
- Known hypersensitivity to NAD+ or any formulation components
- Severe liver disease
Drug interactions
- Chemotherapy agents - NAD+ may affect drug metabolism; consult oncologist
- Blood pressure medications - NAD+ may have mild vasodilatory effects
- Diabetes medications - monitor blood glucose as NAD+ may improve insulin sensitivity
Storage
Follow the storage instructions provided by your pharmacy and on the medication label.
Frequently asked
How quickly will I notice anything?
Patient experience varies. Some patients describe a subjective change in energy or mental clarity in the first few weeks; others report no change. NAD+ is not a treatment for any specific disease and outcomes cannot be guaranteed. Your Pep Club physician will discuss realistic expectations at consultation and monitor progress.
Is the compounded NAD+ preparation different from oral supplements like NMN or NR?
Yes. The compounded NAD+ preparation dispensed by The Pep Club is administered as a subcutaneous injection. Oral NAD+ precursors (NMN, NR) are different products with different routes and different absorption profiles. Your physician will discuss which approach fits your situation.
Where we can ship
Available in every state where The Pep Club has a licensed physician and a licensed pharmacy partner. Check the state availability page for the current list.
Ready to talk to a physician?
Start with our short eligibility intake. If you qualify, a licensed physician reviews your history before any prescription is issued.